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Enzymes are affected by changes in pH . The most favorable pH value - the point where the enzyme is most active - is known as the optimum pH . Extremely high or low pH values generally result in complete loss of activity for most enzymes . pH is also a factor in the stability of enzymes . Beside this, how does low pH interfere with enzyme activity? pH . The measure of the acidity or alkalinity of a solution is referred to as pH . Enzymes have evolved to operate at specific pH values and deviation from this value will lead to a decrease in enzyme activity . This is because a high or low pH can denature enzymes just as high temperatures do . what happens to enzymes at low pH? Describe: As the pH decreases below the optimum, enzyme activity also decreases. At extremely low pH values, this interference causes the protein to unfold, the shape of the active site is no longer complementary to the substrate molecule and the reaction can no longer be catalysed by the enzyme . ...